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At early meiotic times they showed a graded response, and at later meiotic times a threshold effect (delayed or advanced time of transcription).
Studies in S.cerevisiae showed that increasing global histone acetylation by deletion of the Rpd3 histone deacetylase results in earlier association of Cdc45 with late origins and advanced time of activation [2], [4].
In contrast, F344 rats showed an advanced time of VO when fed the 300- or 450-μg genistein/g diet.
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Earthquake Early Warning System (EEWS) is one of the effective ways to mitigate earthquake damage and can provide few seconds to tens of seconds of advanced warning time of impending ground motions, allowing for mitigation measures to be taken in the short term.
In terms of the methodology of advanced time-dependent fracture mechanics, this paper developed an expert system to realize an appropriate combination of material database, condition database and knowledge database.
In the past, in less scientifically advanced times, the best verification of royal legitimacy was for a senior official to be present at a royal birth to ensure no sleight of hand with a warming pan to substitute a boy for a girl.
A striking feature of atypical BSE cases is their advanced age at time of detection.
The Egyptian breast cancer series in our study was consistent with the expected findings of advanced disease at time of diagnosis compared to that ordinarily seen in North America and Europe.
Other patients with significantly lower OS values included those with low KPS (≤50) or advanced age at time of initial diagnosis (≥80) 19.
However, longer delays were associated with more advanced stage at time of treatment, and were not associated with reduced survival once the effect of stage was taken into account.
Breast cancer patients diagnosed during pregnancy and <2 years after birth often have a poor prognosis [ 10- 20]; the tumors are often estrogen-receptor negative and at an advanced stage at time of diagnosis [ 10- 14].
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