However, no significant difference was observed between the PFS of REV7high and REV7low groups in only CCC cases at advanced stages (data not shown).
LETM1 expression levels were not related to the survival rates of patients with advanced stage HNSCC (data not shown, P = 0.374).
In England, in the same period, 42 850 men, aged 50 69 years, were registered with clinically detected prostate cancer and 27% of the cases presented with advanced stage disease (ECRIC data; Table 1).
Additionally, the expression statuses of ezrin, ezrinThr-567 and ezrinTyr-353 proteins were not correlated with the survival rate in patients with advanced stage (III IV) NSCLC (data not shown, P = 0.104, P = 0.288, P = 0.713, respectively, log-rank).
For early-stage (I IIA) cervical cancer patients, the survival analysis demonstrated that high ezrin expression was associated with lower 10-year survival rate (log-rank P=0.030; Figure 4), but there was no significance in patients with advanced stage (IIB IV) cervical cancers (data not shown, log-rank P=0.352).
Preliminary actigraph data from advanced stage breast cancer patients suggested that poor sleep efficiency assessed up to 7 years post diagnosis was associated with cancer-specific mortality over a 10-year follow-up period (Palesh et al, 2014).
Moreover, the Kaplan-Meier curves have also underlined the statistically significant association between beta-catenin overexpression, high degree of differentiation (OS, P < 0.0002; DFS, P < 0.0004), and advanced stage (OS and DFS, P < 0.0001) (data not shown).
Additionally, ezrin overexpression was associated with shortened 10-year survival for patients with early-stage cervical cancer (n=51, P=0.030), but this was not significant in patients with advanced-stage disease (data not shown, n=58, P=0.352), indicating that ezrin overexpression might be an effective biomarker for the prognostic evaluation of early-stage cervical cancer.
Secondly, we did not have data for individuals with advanced stage lung cancers as these patients usually do not undergo surgery for their disease.
Also, although a haplo-insufficient mechanism for SDHD involvement in advanced stage neuroblastoma could be considered, the present data do not provide consistent evidence for this hypothesis.
Perivascular PDGFRβ expression in the tumor area was also positively correlated with advanced stage, tumor vessel density and high Gleason score (data not shown).
