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Recently, whole genome methylation has been extensively examined in mammalian species [ 16, 17] due to advanced sequencing technologies.
The rapid progress in advanced sequencing technologies will permit screening approaches to identify causative uORF mutations in primary material derived from patients.
More and more sequences of proteins are available due to the advanced sequencing technologies, but the biological roles and functions of the proteins are hardly known.
Fusion genes were originally discovered in hematologic malignancies but have been recently found in several solid tumors through the use of modern, advanced sequencing technologies.
To the best of our knowledge, we here provide the first example where advanced sequencing technologies in combination with a back-crossing strategy and a systematic knockout program allowed to identify relevant mutations in an industrial fungus.
Advanced sequencing technologies have enabled molecular epidemiologic studies of viruses in which whole gene and complete genome data are used to enhance and clarify the evolutionary dynamics of viral infectious disease (11 ).
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In general, biological sequence data are accumulating rapidly as a result of advanced sequencing technology and concerted genome projects, at a greater rate than growth in computing efficiency.
Our primary objective is further testing of the existence of subtype-specific prognostic markers using data from a more advanced sequencing technology.
Two years later, the same genome was resequenced utilizing more advanced sequencing technology and analytical methods resulting in the detection of a previously unidentified frameshift deletion in DNMT3A.
In our study, all types of lncRNAs, including those of sense, antisense, intronic and intergenic lncRNAs were identified using the advanced sequencing technology and analytic methods such as strand-specific sequencing and Cuffcompare analysis.
Similarly, some novel genetically encoded MRI contrast agents and advanced sequence technologies have been used to detect gene expression [ 16– 16].
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