Making use of advances in sequencing platforms and bioinformatics tools, recent studies have shown that metagenomics can even determine the whole-genome sequences of pathogens, allowing inferences about antibiotic resistance, virulence, evolution and transmission to be made.
With continued advances in gene sequencing platforms, more complete genomic databases, and advancements in bioinformatics, many of these constraints should resolve in the near future.
The rapid advances in DNA sequencing platforms will help build the tools to query those variants in the near future in a comprehensive fashion, mitigating some of the shortcomings of HapMap-inspired SNP arrays.
Advancing the Biohub's overarching projects will require technologies such as the CRISPR genome-editing technology, advanced cryo-EM, single-cell sequencing platforms as well as single-molecule imaging technologies and the computational infrastructure needed to analyze giant datasets, Tjian said.
Recent technological advances in high-throughput sequencing platforms have made it possible for researchers to generate comprehensive information on rare variants in large samples.
Yet, with the rapid pace of advances in next generation sequencing platforms, more exhaustive surveys appear more tractable than ever before.
Whole genome sequencing, spurred on by recent advances in next-generation sequencing platforms, is a promising approach to facilitate rapid identification and selection of such strains based on gene-trait matching.
The availability of cost and time efficient genotyping methods for SNPs using next-generation sequencing platforms will certainly advance comparative genomic and population genetic studies of these species.
Due to advances in high-throughput DNA sequencing platforms, including Roche 454, Illumina, SOLiD, Ion Torrent, and PacBio20, researchers can better understand the function, evolution, environmental adaptation and potential application of marine bacteria.
Advances in the next generation sequencing platforms, and RNAi screens, continue to spearhead the identification and validation of lesions that drive tumorigenesis and confer chemoresistance to malignant cells.
The advances in sequencing technology and the variety of sequencing platforms available has allowed for a significant increase in the number of fully sequenced phage genomes [ 27].
