Sentence examples for advanced replication timing from inspiring English sources

Inhibitors of histone deacetylases cause advanced replication timing, and late replicating chromosomal regions colocalize with hypoacetylated chromatin [25], [26].

We wanted to test whether this advanced replication timing in checkpoint-deficient cells would also apply to the 8-kb THF described above in a plasmid context.

Alternatively, other pre-replicative components, Sld3 Sld7, or other replication-initiation proteins, such as Cdc45, might be the relevant targets of kinetochore DDK for advancing replication timing at pericentromeres.

Intriguingly, in both yeast species, DDK is also involved in advancing replication timing at centromeric regions, which is the focus of the next section.

Intriguingly, fission yeast DDK is also recruited to centromeric regions to facilitate robust cohesion and to advance replication timing (Fig 5; [ 79, 135]).

However, two other roles facilitating robust sister chromatid cohesion and advancing the replication timing of centromeric regions have recently emerged.

To advance the replication timing of the centromeric region, in budding yeast, DDK is recruited to the kinetochore by the Ctf19 kinetochore complex in telophase to early G1 phase [ 57].

In higher eukaryotes, chromosome structure is tightly linked to gene regulation and to replication timing [ 39].

How does DDK promote pericentromeric cohesion and advance DNA replication timing in budding and fission yeast?

Escape from silencing in ICF cells was associated with a marked advance in replication timing from a late to an active X-like pattern [10].

Notably, the formation of a neocentromere in C. albicans advances the replication timing of its chromosomal site [ 131], which suggests that the presence of a centromere per se changes the timing of replication.