Sentence examples for advanced pathway from inspiring English sources

Although high-resolution techniques and advanced pathway extraction tools are available (Breitling et al., 2006; Gipson et al., 2008), it is still not always possible to uniquely identify compounds, as the MS 'peaks' are not sufficiently accurate.

Lastly, BCML containing deeper descriptions of biological knowledge turns out to be a format extremely suitable for advanced pathway analysis methods, as well as creation of knowledge-based online resources.

Hyperglycemia and hyperlipidemia affect a number of pathways including aldose reduction pathway, advanced glycation end pathway (AGE), reactive oxygen intermediate pathway, and PKC pathway.

Although multiple pathways are involved in mediating tissue damage, including the polyol pathway, advanced glycation end product formation, protein kinase C activation, and the hexosamine pathway, a common feature is increased oxidative stress marked by elevated levels of reactive oxygen species (ROS) (1).

So far, proposed mechanisms include altered metabolism of glucose via the polyol pathway, advanced glycation end products, increased protein kinase C (PKC) activity, altered neurotropism, perturbation of lipid metabolism, ischemia and reactive oxygen species [4], [6], [9], [10].

The widespread prevalence of diabetes in developing countries is expected to increase the magnitude of blindness due to cataract and the cellular and molecular mechanisms underlying the pathogenesis of cataract showed the involvement of polyol pathway, advanced glycation end products and oxidative stress [ 36].

La Cañada High School has been awarded $443,000 in state matching grants — a figure that could rise to $997,000 in the next two years — to build and advance career pathways for students, Principal Ian McFeat told school board members Tuesday.

Therefore, translational research can be advanced through many pathways leading to a process by which knowledge can travel at a faster pace to practice, thus ensuring that discoveries and innovations reach the patients or populations for whom they are intended.

In only a couple years, our understanding about RNA methylation pathways advanced with remarkable speed and the importance of RNA methylation and its role in human diseases is now widely recognized.

Several molecular mechanisms have been implicated in hyperglycaemic-induced endothelial damage: activation of protein-kinase C isoforms, increased hexosamine pathway flux, increased advanced glycation end product formation, increased polyol pathway flux and activation of the proinflammatory nuclear transcription factor kappa-B [ 7].

Here we review advanced methods of quantifying pathway activity and highlight specific examples where these approaches have uncovered potential opportunities for therapeutic intervention.