The phrase "advanced origin" is correct and usable in written English.
It can be used in contexts discussing the origins of something that is sophisticated or developed, often in fields like technology, science, or philosophy.
Example: "The researchers traced the advanced origin of the technology back to early experiments in artificial intelligence."
Alternatives: "sophisticated origin" or "developed source".
These data suggest that the 3′ URA3 sequences are capable of advancing origin activation time.
Our results provide the identification of a potential third mechanism by which DNA sequences can advance origin activation time.
Currently, there are two examples of DNA sequences that are known to advance origin activation time, centromeres and forkhead transcription factor binding sites.
The forkhead transcription factors, Fkh1 and Fkh2, are capable of advancing origin activation time over a distance of at least 500 bp (Knott et al. 2012).
Although a centromere's ability to advance origin activation time is bidirectional, the centromere also has a greater timing effect on closer origins than on more distant ones (Pohl et al. 2012).
These results could also be obtained if the bias determinant was effective only on plasmids and incapable of advancing origin activation time in the context of a linear chromosome.
By combining deletion and linker scanning mutational analysis with two-dimensional gel electrophoresis to measure fork direction in the context of a two-origin plasmid, we have identified and characterized a 19- to 23-bp and a larger 584-bp DNA sequence that are capable of advancing origin activation time.
Integration of a centromere close to ARS1 N in this plasmid (pΔ9C) resulted in a marked bias toward ARS1 N use, indicating that sequences that are known to advance origin activation time in chromosomal DNA can in fact impose an origin use bias in pN&S.
If the bias determinant were to impart early activation to ARS1 S we would expect that other DNA elements, such as centromeres, that are known to advance origin timing would produce a similar bias when placed in the context of the two-ARS plasmid.
In contrast, inhibition of S-phase checkpoint kinases advances origin firing in both yeast and human cells [15], [17].
