The phrase "advanced intractable" is not standard in written English and may cause confusion.
It could be used in a context discussing complex problems or conditions that are difficult to manage or treat, but it would need clarification.
Example: "The patient was diagnosed with an advanced intractable condition that required specialized care."
Alternatives: "complex persistent" or "severe unmanageable".
Mori et al. recently reported on three advanced cancer patients with intractable pain, the cause of which was attributed to severe psychosocial distress [ 12].
Few surgeons would hesitate to recommend TKA for a 65-year-old patient who presents with the radiographs displaying far advanced osteoarthritis and who has suffered from intractable knee joint symptoms that compromise daily activities.
One of these viruses, known as Onyx-015, has been used with considerable success to treat intractable head and neck cancers and has now advanced to Phase 3 trials.
Although developments in transient expression resulting from deeper understanding of underlying fundamental processes have enabled advanced synthetic biology in plants, our experience is that the transient synthetic reconstruction of biological systems has also revealed the workings of otherwise intractable processes.
The organization will reward an unprecedented amount of prize money to researchers making advances in curing intractable diseases and extending human life, the Guardian reported.
In this study, we have used bioinformatics approaches to analyze available C. parvum transcriptome data and genome sequence to advance our understanding of possible regulatory mechanisms in this experimentally intractable parasite.
As North Korea kept advancing its nuclear program, Beijing saw its interests increasingly compromised by an intractable North Korean government and growing U.S. defensive posturing.
Since the dawning of civilization, humankind has made remarkable progress in advancing public health and improving people's health, but in many ways, we are facing intractable and emerging health problems.
North Korea and the U.S. have long been in an intractable diplomatic standoff, but the relationship has deteriorated this year as Pyongyang's nuclear and missile programs rapidly advance.
