Advanced age, poor functional status at baseline, impaired cognition, and limited support at home are risk factors for adverse outcomes.
Several risk factors of functional decline in older persons have been described previously following acute illness including advanced age, previous impaired functional status, and lower scores on the abbreviated MMSE [ 15, 24].
In the analysis, predictors significantly associated with TB-free survival time were bedriddenness or ambulatory functional status, advanced WHO clinical stage, and low CD4 count at baseline (Table 3).
Many patients diagnosed emergently have advanced disease, multimorbidity, low functional status, or poor prognosis, which could postpone or preclude curative resection, particularly African Americans and those of low SES who often present with more advanced disease [ 14].
impact on the cognitive function and functional status.
A retrospective ART cohort study in Ethiopia reported weight loss ≥10%, bedridden functional status at baseline, advanced WHO clinical stage and CD4 cell count ≤200 cells/mm as independent predictors of death (17).
Several factors may explain this progress, including a better selection of patients on the basis of previous functional status and advances in the management of acute complications such as variceal bleeding [ 44], hepatorenal syndrome [ 45], or septic shock as highlighted in the present study.
Advanced age, debilitation, impaired pre-illness functional status, chronic disease, genotype, and socioeconomic environment can also predispose to long-term sequelae on survival.
The assessment measures functional status, comorbidity, cognitive function, psychological state, social support, and nutritional status.
The construct functioning is synonymous with functional status [2, 8].
Although the past two decades have seen considerable development and evaluation of self-report functional status measures [ 3- 7] these advances have not been paralleled to the same extent in performance measures.
