The phrase "advanced emphysema" is correct and usable in written English.
It can be used in medical contexts to describe a severe stage of emphysema, a chronic lung condition.
Example: "The patient was diagnosed with advanced emphysema, requiring immediate intervention and management."
Alternatives: "severe emphysema" or "end-stage emphysema".
For instance, restricting attention to advanced or far advanced emphysema reduces the rate in the male smokers to 134/839 (16.0%), and in never smokers to zero, so still indicating an extremely high RR.
AUERBA involved an examination of whole-lung sections prepared from lungs removed at autopsy, with 816/839 (97.3%) male current cigarette smokers and 20/176 (11.4%) male never smokers of any product diagnosed as having minimal, slight, moderate, advanced or far advanced emphysema.
Comparison of survival curves by log rank tests showed improved survival in patients with pulmonary fibrosis and advanced emphysema compared with patients with pulmonary fibrosis without emphysema (P = 0.014) and patients with pulmonary fibrosis and trivial emphysema (P = 0.015).
The patients in our study who had advanced emphysema did have higher lung volumes (vital capacity and TLC) than patients without emphysema, a finding not surprising due to the presence of emphysema and a finding which had been previously reported in patients with emphysema and fibrosis [ 16].
Volunteers were excluded if they were current smokers or if they had evidence of chronic infection, a history or evidence of malignancy within the past 5 yr, clinical cardiovascular disease, advanced emphysema, advanced Parkinson's disease, resting blood pressure >170 mmHg systolic or >100 mmHg diastolic, or diabetes (self-report or fasting plasma glucose ≥ 126 mg/dL).
Advanced emphysema is characterized by destruction of lung parenchyma and augmentation of anatomic connections for air passage between adjacent lung lobules.
In our cohort of patients, survival was improved when advanced centrilobular emphysema was present in patients with pulmonary fibrosis.
The novelty of our findings, based on our quantitative approach, is the improved survival in patients with fibrosis who concurrently had advanced centrilobular emphysema.
Based on CT scans and lung function testing in four of these patients, advanced pulmonary emphysema based on chronic obstructive pulmonary disease was diagnosed, increasing the risk of radiation induced pneumonia [ 19].
We have demonstrated that patients with pulmonary fibrosis and advanced centrilobular emphysema, a well established chronic inflammatory condition of the lung, have a better prognosis than patients with pulmonary fibrosis without emphysema or those with fibrosis and trivial amounts of emphysema.
Or, to put it another way, if you were the one who had metastatic cancer — or, for that matter, a similarly advanced case of emphysema or congestive heart failure — what would you want your doctors to do?
