For women with advanced disease, efficacy after first-line taxane-based regimens is extremely poor (Dellinger and Monk, 2009; Dizon, 2010).
In patients with advanced GIST, imatinib efficacy was initially described in a single patient.
Although chemotherapy remains the main treatment modality for patients with advanced disease, the efficacy of systemic chemotherapy appears to be limited or controversial in high-grade salivary gland carcinomas.
In advanced disease, the efficacy of first-line bevacizumab including chemotherapy has been proven in three randomized clinical trials [ 7- 9] and its activity has been recently shown as second-line option [ 10].
However, most previous clinical trials have not demonstrated adequate proof of immunotherapy efficacy for advanced HCC., On the other hand, our clinical trial of glypican-3 GPC3 -derived glypican-3 GPC3 -derivedadvanced HCC demonstrated that the induction of peptide-specific cytotoxic T lymphocytes (CTLs) siglypican-3 GPC3 -derivedith peptide survaccine
In total, 14 items were used to measure three factors of the construct with sufficient reliabilities: Self-efficacy in basic operational skills (ω = .79, 6 items), self-efficacy in advanced operational and collaborative skills (ω = .72, 4 items), and self-efficacy in using computers for instructional purposes (ω = .76, 4 items).
Gynecological cancers (GCs) are often diagnosed at advanced stages, limiting the efficacy of available therapeutic options.
Irinotecan, a topisomerase I inhibitor, and oxaliplatin, a new platinum compound, have proven efficacy in advanced colorectal cancer resistant to 5-fluorouracil.
To determine the safety and efficacy of advanced electrothermal bipolar vessel sealing (EBVS) during vaginal hysterectomy by evaluating urinary complications, overall complications, and reoperation rate.
Pembrolizumab demonstrates similar efficacy in advanced melanoma.
