The phrase "advanced difficulty" is correct and usable in written English.
It can be used to describe a level of challenge that is higher than average, often in contexts like games, tests, or tasks.
Example: "The game offers three levels of play: easy, medium, and advanced difficulty."
Alternatives: "high difficulty" or "expert level".
By taking remedial action and gauging the impact by measuring security and also regulatory compliance-related variables, most advanced difficulties can be located, identified and remedied quickly.
It's a rich additional feature, and one that's required to excel in the advanced difficulties of the game, though I found playing on easier modes meant that if you weren't altogether sure of how best to play the new mechanic when starting out, it wouldn't appreciably hurt your experience.
At more advanced stages, communication difficulties limit exchanges during consultations and the patient's participation in his/her own care [ 5].
Although the majority of clinical trials to date have used autologous patient cells as the starting material to generate CAR T cells, this strategy poses significant manufacturing challenges and, for some patients, may not be feasible because of their advanced disease state or difficulty with manufacturing suitable numbers of CAR T cells.
State-of-the-art WCET analysis techniques are hampered by the soaring cost and complexity of obtaining accurate knowledge of the internal operation of advanced processors and the difficulty of relating data obtained from measurement observations with reliable worst-case behaviour.
"This is really a technical advance to get at this extraordinary complex diversity, it helps explain why we have such difficulty with advanced diseases".
Dementia patients, in particular in the advanced stages, may have difficulty in communicating their symptoms.
As well, reliability analyses suggest that CIS and IM cases should be combined into a case group of "advanced adenomas" given the difficulty in reliably classifying these lesions [ 35].
The vast amount of generated sequencing data is subsequently analyzed using a variety of analytical tools, with progressively increased level of difficulty and advanced requirements for computational and genomics expertise.
Patients with advanced neurologic disease with aphonia, difficulty with speech initiation, dysphagia, or ambulatory difficulty are less likely to respond to this procedure and should be so informed.
