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We believe that both obesity and the advanced accumulation of the AGEs may be contributing to this osteoarthritic phenotype, however, the manner of this still remains unclear.
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When fed to the aged Tg2576 mice with advanced amyloid accumulation, curcumin resulted in reduced soluble amyloid levels and plaque burden [ 60].
At the same time, however, some pre-frail and apparently healthy adults may not yet exhibit age-related disease traits and the advanced deficit accumulation to which many frailty measures are particularly sensitive.
(2) Meerwaldt R et al. (2004) Simple non-invasive assessment of advanced glycation endproducts accumulation.
In advanced malignancies, the accumulation of PINP and PIIINP in abdominal space, possibly due to increased synthesis and/or failed resorption, may promote ascites formation.
Strikingly, this was only observed immediately after the lag phase, during the reconstituted VS stage, whereas at more advanced stages sugar accumulation seems instead to be favored by high temperatures.
Excess circulating glucose also may bind proteins, lipids, and nucleic acids, resulting in the formation and accumulation of advanced glycation end products (36, 37); accumulation of advanced glycation end products in the vessel wall may contribute to inflammation, oxidative stress, and endothelial dysfunction.
Diabetes mellitus involves the accumulation of advanced glycation end products (AGEs).
Accumulation of advanced glycation endproduct (AGE) has been implicated in the pathogenesis of diabetic complications.
One of the major age-related changes in cartilage is the accumulation of advanced glycation end products (AGEs).
The experimental studies suggested the hypothesis that the accumulation of advanced glycation end-products (AGEs) could induce hearing impairment.
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