Here we describe results from advanced accelerated molecular dynamics (aMD) simulations, coupled with adaptively biased force (ABF) and thermodynamic integration (TI) free energy methods.
Compared to single knockout parental strains, double knockouts, fed a normal chow diet, simultaneously exhibit advanced accelerated atherosclerosis, glomerulonephritis, osteopenia, and lupus-like autoimmunity starting at five months of age [ 16].
However, advanced (accelerated or blast crisis) phase CML and Ph+ ALL patients show significantly decreased response rates to treatment with imatinib monotherapy, with relapse common within a year (Ottmann et al, 2002; Sawyers et al, 2002); acquired resistance is less commonly observed in the case of newly diagnosed Ph+ ALL patients receiving combination therapy with chemotherapy.
But as Firefox and others have gained market share, competition has sped feature advances, accelerating the development and evolution of javascript and other languages and standards.
After halting the Japanese the Allies moved onto the offensive in late 1942, with the pace of advance accelerating in 1943.
Technical advances accelerated progress in computer chess during the 1970s and '80s.
The Highlander, fitted with Toyota's most recent fuel-cell advances, accelerated and handled indistinguishably from a gas-powered version, with none of the vibration typical of a piston engine.
Scientific advances accelerated as a result of the ground-breaking Human Genome Project enable the quantification of genetic information that underlies such human variability in susceptibility and the cellular mechanisms of disease.
We predict that advances will further accelerate and that the resulting genomic data sets will lead to unprecedented new insights in to vertebrate gene functions and evolutionary mechanisms.
Some advanced cadets may "validate" out of the base-level classes and take advanced or accelerated courses earlier as freshmen or sophomores.
