The phrase "advance compounds" is not standard in written English and may cause confusion.
It could be used in a specific context related to chemistry or linguistics, but clarity is essential.
Example: "The research focused on the development of advance compounds that could improve energy efficiency."
Alternatives: "advanced compounds" or "progressive compounds".
Advanced compounds were the culmination of iterative library design and possess excellent biochemical and cellular potency, as well as acceptable PK and efficacy in animal models.
A sequence of in vitro assays followed by in vivo testing in validated animal models to assess the activity against Mycobacterium tuberculosis, pharmacology and toxicity is generally used for advancing compounds against tuberculosis in a preclinical stage.
An often cited criticism in advancing compounds to in vivo studies based on in vitro bactericidal effect is the lack of its predictive value.
These results provide the basis for a novel strategy of antimalarial drug development by advancing compounds that have dual mechanisms of action.
The author cited a need to develop pre-clinical models that are more predictive of human OA progression, or accept the risks associated with advancing compounds in development that demonstrate moderate results in already established models of OA.
Multiple strategies have evolved during the past few years to advance epigenetic compounds targeting DNA methyltransferases (DNMTs).
In short, we need a more efficient R&D ecosystem able to more rapidly advance promising compounds through the research, development and approval process, while also ensuring patient access.
However, multi-facetted SAR information obtained from heterogeneous compound sources must ultimately again be utilized to advance individual compound series, which is a challenging task.
As high-dimensional omics research has advanced, the compound covariate (or compound score) has generally been held as a simpler and more straightforward approach.
Alexander Hoepping and René Smits are employees of ABX advanced biochemical compounds, Radeberg, Germany.
