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In England, the abolition of trial by ordeal led to the adoption of trial by jury for criminal cases.
Both of these choices will also impact on the adoption of trial findings into clinical practice.
Larger multicentre RCTs with wider participation improves generalisability and facilitates adoption of trial findings into clinical practice.
First, we ex amine the level of confidence we have in the trial results, second, we predict the impact of early adoption of trial results, and third, we predict the impact of late adoption of those trial results.
(3) Impact of late adoption To calculate the opportunity cost to society of delaying adoption of trial results by an additional 5 years, we first determined the magnitude of the population for whom this technology would be applicable.
Results are summarised and presented narratively under the following headings: 1) identifying clinically relevant research questions; 2) education and training; 3) conduct of multicentre RCTs and 4) dissemination and adoption of trial results.
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Applying an evaluative framework for the adoption of clinical trial results to the TARGIT-A IORT therapy trial results in the assessment that the trial results are stable, early adoption would lead to minimal adverse impact, and substantially less resource use.
We propose a decision framework for the adoption of clinical trial results that includes three components.
Adoption of clinical trial findings from SBPS clearly occurred but was limited despite clear recommendations and subsequent dissemination.
More work is therefore needed to understand and circumvent the barriers to adoption of clinical trial evidence.
@dannysullivan would prefer Google unleash the hounds of celebrity and brands, surprised as he and we are that the Plus team was caught flatfooted by the viral adoption of the field trial, or whatever Danny calls it.
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