Whilst it may be intuitively obvious that the study of hERG1b-specific mutations [16] or N-terminal long QT syndrome (LQTS) mutations (∼20% of hERG1a-linked LQTS mutations occur in the N-terminus [26]) warrants the study of hERG1a/1b heteromeric channels, until now there may not have been a clear rationale to adopt this approach when studying mutations that are distant from the N-terminus.
Justice Sonia Sotomayor did not seem inclined to adopt that rationale, calling it "a Nuremberg defense," in which "simply because supervisors decide that it's O.K. that exculpates someone from responsibility".
Many could adopt the rationale of accommodating the behavior rather than condoning the behavior as a more palatable and less controversial stance.
The rationale that prompted us to adopt this approach is that the pathophysiological consequences, in terms of genetic instability and risk of cancer development for the oral mucosa, of either large or small chromosomal aberrations are not fully established.
33 In accordance with the rationale behind the concordat approach, we do not advocate that other collaborations simply adopt this example of a concordat 'as is'.
Last summer, a North Carolina federal district court temporarily blocked enforcement of the law against student plaintiffs, adopting the rationale of Grimm's Fourth Circuit case, which deferred to Obama's Title IX guidance.
In adopting that rationale for making war, Washington was in effect radically revising the terms of international diplomacy.
Adopting the rationale of the so-called Markham rotation [3], one can superimpose pixel-by-pixel a particular GPxI with other GPxIs that were created by frame-shifts of 1,2,3,f the original sequence.
This paper describes how semantic mapping can simplify usage of HL7 Version 3 Clinical Document Architecture (CDA) and reports on the rationale for adopting this approach in three particular use cases and lessons learned from the practical application experience.
The rationale for adopting this approach is both scientific and ethical.
