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At multivariate analysis, a lactate level ≥2.0 mmol/l had 1.75 times increased possibility of admission per unit increase in lactate (95% CI 1.11 to 2.75, p = 0.02).
However, lactate level ≥4.0 mmol/l had 4.25 times increased possibility of admission per unit increase in lactate (95% CI 2.8 to 6.5, p < 0.001).
Univariate analysis in our study shows that any lactate ≥2.0 mmol/l had 1.10 times increased possibility of admission per unit increase in lactate (95% CI 1.07 to 1.13, p < 0.001).
In the unadjusted model, lactate ≥2.0 mmol/l results in a 1.10 times (95% confidence interval (CI) 1.07 to 1.13; p < 0.001) higher risk of admission per unit increase in lactate.
But a lactate level ≥4.0 mmol/l has 4.25 times increased possibility of admission per unit increase in lactate at a 95% CI of 2.77 to 6.52 (p < 0.001).
The adjusted model that also includes a lactate level ≥2.0 mmol/l has 1.75 times increased possibility of admission per unit increase in lactate at a 95% CI of 1.11 to 2.75, but the level of significance is less (p = 0.02).
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The resulting 2,406 dermatological admissions (Table 1) represented 0.51% of all admissions in the database, or approximately two dermatological admissions per unit per year.
The total number of admissions per unit rose by 24% throughout the study period; however, the number of CAP ICU admissions rose by 128% from 12.8 per unit in 1996 to 29.2 per unit in 2004 (p < 0.001).
The rationale for using species-to-mass concentration ratios in the second stage was that in the first stage the admission risk was estimated per unit of the total PM2.5 mass, which encompasses all measured species, and therefore effect modification by the species was best expressed on a per unit of PM2.5 mass basis.
After exclusion of 11 units contributing less than six months' worth of data, 33 538 admissions from 170 units were available for calculating the volume of admissions with severe sepsis per unit per year.
The primary exposure of interest was volume of admissions with severe sepsis per unit per year.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com