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In conclusion, the administration of long circulating P-DOX resulted in enhanced tumour accumulation with a concomitant increase in therapeutic efficacy.
However, AmB which requires intravenous administration of long duration is highly toxic and has frequent adverse effects, including infusion-related fever and chills, nephrotoxicity, hepatotoxicity and hypokalemia [ 7].
A study in humans indicates that whether or not the nociceptive input of surgery was blocked through the administration of long acting local anesthesia, overall postoperative pain perception was the same [ 31].
In animal models, the application of hyperthermia to subcutaneous tumors concomitant with or prior to intravenous administration of long circulating liposomes results in a marked increase in liposome accumulation within tumor tissue [ 22, 23].
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Our purpose was to determine whether preemptive administration of long-acting local anesthetics before vaginal hysterectomy will improve postoperative pain.
Similar results have been observed after administration of long-acting somatostatin 14.5 to 11.4 days prior to PET/CT examination [30].
The intramuscular (IM) administration of long-acting injectable (LAI) aqueous nano-/microsuspensions elicits a chronic granulomatous injection site reaction, which recently has been hypothesized to drive the (pro drug dissolution and systemic absorption resulting in flip-flop pharmacokinetics.
The patients were randomized into two groups after the administration of long-acting GnRH agonist 2 4 times within a 4-week interval; highly purified FSH (FSH-HP) and hMG (Group A, n=26), FSH-HP only (Group B, n=19).
To address concerns regarding potential elevations of blood glucose levels after chronic administration of long-lived glucagon constructs, construct 1 was administered to diet-induced obese mice for 28 days.
The intrathecal administration of long-acting local anesthetics and opioids was related to higher incidence of POUR [ 1].
This can be achieved through administration of long-duration experimental sessions, where mental fatigue can occur [ 15, 16].
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