The administration of increasing anesthetic doses can lead to a paradoxical state of excitement in the patient prior to decreases in the level of consciousness.
Specific immunotherapy is based on the administration of increasing doses of allergens to allergic patients with the aim of inducing a state of antigen-specific unresponsiveness.
Our previous work showed that conditioned place preference (CPP) can be induced by administration of increasing doses of morphine in rhesus monkeys.
In a separate experiment, the CGRP antagonist telcagepant was added to either the luminal (10-6 M) or the abluminal perfusate (10-7-10-6 M) 30 minutes before administration of increasing concentrations of abluminal αCGRP.
Traditional phase 1 oncology trials consist in the administration of increasing doses of the experimental compound to successive cohorts of patients until the maximal tolerated dose is reached.
By incremental administration of increasing amounts of drug, hypo-responsiveness of these cells is induced without anaphylaxis occurring.
administration of increasing PPF concentrations of 1, 10, 30, or 100 μl/10 μl (n = 8 for each dose) for 10 days.
With regard to the HoMS, it was investigated whether the administration of increasing amounts of microspheres would lead to signs of toxicity.
In this study, administration of increasing concentrations of BMS-75807 to Rh41 cells for approximately 5 months resulted in the generation of a clone resistant to BMS-754807.
The data indicate that intrathecal administration of increasing concentrations of -CPP or PPF produced a significant dose-dependent antinociceptive effect with respect to monoarthritic rats receiving saline.
