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20 Data regarding the disposables used for drug administration were based on expert advice.
Contraindications for the volume administration were based on the evidence of fluid overload and/or of hydrostatic pulmonary edema.
Doses for free drug administration were based on our previous studies in which neuroprotection was achieved with free VPA and based on the literature for free N-acetylcysteine.
Estimates for timing of pre-operative questionnaire administration were based on an analysis of those patients for whom date of surgery was available through linkage with HES.
The doses of the opioid antagonists and timing of administration were based on previous studies conducted by Choi et al. [ 30] and Reeta et al. [ 31].
Note, that the choice of dose and route of administration were based on the previous demonstration that Cl-amidine reduces disease severity in the murine collagen induced arthritis model of rheumatoid arthritis [ 5].
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