The phrase "administration of very" is not correct and does not convey a clear meaning in written English.
It seems to be an incomplete thought and lacks context to determine its intended use.
Example: "The administration of very complex systems requires specialized knowledge."
Alternatives: "management of highly" or "oversight of extremely".
Conclusions: The administration of very low doses of glucocorticoids using autologous erythrocytes is possible, with benefits for patients and without side effects.
In accordance with the findings of Kastrup et al. [22], it is our belief that the short-term administration of very high doses of catecholamines, especially during the first hours of septic shock, does not influence outcome and may be beneficial, particularly in instances of very low diastolic blood pressure which reflects a very severe hyporesponsiveness to vasopressors.
Our data confirm that biperiden is safe, even after administration of very high doses.
However, elevated concentrations of BACE1 around plaques might necessitate the administration of very high BACE1 inhibitor doses in order to significantly reduce peri-plaque Aβ generation, if the amyloid burden is great.
Recently, clinical research has demonstrated that oral tolerance to peanut can be induced by intentional oral administration of very low, slowly escalating doses of peanut (Jones et al., 2009).
In children, clinical manifestations of adrenal suppression as a consequence of the use of ICS are extremely rare [ 34] and seem to be related to the administration of very high doses of an ICS for prolonged periods of time.
It is therefore possible that administration of a very high dose might have resulted in very high blood concentrations.
That is, until about the middle of May, when preparations began in earnest for administration of his very first state standardized test.
As described in this report, however, i.v. administration of a very high dose of rFVIIa did not induce hemostasis in our first patient with DAH.
However, increased metastasis occurred only upon administration of a very high sunitinib dose, but not when lower, clinically relevant doses were used.
Another study of toxicity performed with chloroform and hexane soluble fractions of X. strumarium reveals that the administration of a very high dose (5 g/kg body weight) for acute toxicity determination could not make any abnormal changes at gross as well as histopathological levels in the treated animals [ 28].
