Sentence examples for administration of vector from inspiring English sources

It has been our central hypothesis that localized and controlled administration of vector in the cornea via minimally invasive simple surgical techniques would allow targeted therapeutic gene delivery into desired cells of the cornea, in vivo.

A recent clinical trial using intravenous administrations of AAV2/8 in patients with hemophilia B has supported this paradigm in humans; some treated patients exhibited multiyear stable factor IX levels following a single administration of vector.

In addition to their excellent safety profile, the most attractive attribute of these vectors is their ability to mediate persistent therapeutic transgene expression after a single administration of vector in a variety of animal models.

Several Tat PTD fused proteins have been reported as potential therapeutic strategies for cancer (Mann and Frankel, 1991; Derossi et al, 1996; Elliott and O'Hare, 1997; Vivès et al, 1997), but the quantity of protein transduced into tissues would be lower than that from administration of vector DNA.

Suppression of local tumor growth is thereby beneficial to the patients and an intrapleural administration of vectors is technically feasible.

An additional consideration is that to achieve sustained silencing of chronic HBV infection, repeated administration of vectors may be necessary, in which case avoidance of immunostimulation is important.

A local treatment can thereby be beneficial to the patients, and gene therapy with an intrapleural administration of vectors is one of the potential therapeutics.

We also demonstrated that co-administration of vectors containing BPV1 L1 ± L2 DNA with CRT/E7 DNA led to the generation of L1/L2-specific CD4+ T cell immune responses as well as L1-specific neutralizing antibodies.

We also demonstrated that co-administration of vectors expressing BPV-1 L1 and/or L2 DNA with CRT/E7 DNA led to the generation of L1/L2-specific CD4+ T cell immune responses and L1-specific neutralizing antibodies.

We showed that co-administration of vectors containing codon-optimized bovine papillomavirus type 1 (BPV-1) L1 and L2 in combination with DNA vaccines could elicit enhanced antigen-specific CD8+ in both CRT/E7 and ovalbumin (OVA) antigenic systems.

In the current study, we showed that co-administration of vectors containing codon-optimized BPV1 or HPV-16 L1 or L2 in combination with DNA vaccines could elicit enhanced antigen-specific CD8+ in both CRT/E7 and ovalbumin (OVA) antigenic systems.