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Similarly, administration of various doses of follicle stimulating hormone during superovulation did not show any correlation with LDH level.
The method of choice for defining this relationship is the use of a well-understood probe (or radioligand) which allows the quantification of target availability at baseline and following the administration of various doses of a novel drug.
In the first set of experiments, hypoglycaemic effects of oral administration of various doses (50, 100 and 200 mg/kg) of the extract were examined in normoglycaemic and glucose-hyperglycaemic rabbits.
The administration of various doses of the extract was done by gastric intubation once a day, for 28 consecutive days [ 11].
Although we have consistently shown that acute administration of various doses of METH can cause substantial alterations in gene expression [ 14- 16, 47], the epigenetic events involved in these changes have yet to be characterized.
To determine whether there was a difference in the incidence rate of an adverse event following administration of various doses of fimasartan, a Chi-squared or Fisher's exact test was used.
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Results are given of an experimental study of the carcinogenic activity of various doses of benz[a]pyrene (0.005, 0.02, 0.1, 0.5, and 2.5 mg) on rats by using a tenfold intratracheal administration.
The effect of PL on SW480 tumor growth in nude mice was also evaluated using different routes of administration and various doses (25-100 μg per mouse) for 14 d from the day of tumor inoculation.
The anti-inflammatory properties of ACRH and QRF were tested using the Miles vascular permeability assay and the murine air pouch granuloma model following oral administration at various doses.
Poly(ADP-ribose) polymerase-1 activity was also measured in mouse PBMCs, and brain, liver and tumour homogenates at various times after administration of rucaparib at various doses and routes using a validated assay as previously described (Plummer et al, 2005; Daniel et al, 2010).
Thus, as a desirable alternative to invasive dosing, such as chronic intraperitoneal injections, the administration of various drugs via food pellets can be very efficient.
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