31 In FACS analysis, the ratios of L-GMP in mice treated with DZNep were significantly decreased compared with control mice, while administration of typical cytotoxic agent did not reduce them (Fig. 1e, Fig. S2).
Parkinsonism was measured by a certified rater using the Unified Parkinson's Disease Rating Scale (UPDRS) in both the practically defined "off" state (i.e. following at least a 12-h holiday from antiparkinsonian medications) and the "on" state (i.e. after administration of typical medication regimen).
We therefore wished to determine the serum levels of digitoxin upon administration of a typical dose used in published reports and approximately 20 times lower than the maximum tolerated dose [5], [6], [14], [15].
The daily drug cost (including material and labour costs for dispensing, preparation, and administration) of a typical ciprofloxacin 400 mg IV regimen administered twice daily is $72.62 [ 4].
Moreover, fluid was titrated to achieve a target end diastolic filling pressure, and this mode of administration is typical of the fluid management approach taken in the clinical setting.
The NT receptor antagonist SR 142948A reduced the high levels of PPI during D1 and P. In contrast, when tested at a time of day in which PPI was low in D1 females, administration of both the typical antipsychotic drug haloperidol and the NT receptor antagonist significantly increased PPI.
More relevant are respiratory depression and ensuing hypercapnia, which limit the administration of meperidine in typical ward settings.
These studies involved the administration of GlcN at typical supplemental quantities (1500 mg), for treatment periods of between 1 and 90 days.
STZ administration affected the levels of typical blood parameters characteristic for diabetes, which are also accepted values in diabetes diagnostic (glucose, insulin and HbA1c).
But more importantly, this strongly suggested that the craniofacial and intestinal phenotypes obtained after phosphoramidon administration were typical of EDNRA and EDNRB inactivation, respectively (Hosoda et al., 1994; Kurihara et al., 1994; Gariepy et al., 1996; Kempf et al., 1998; Yanagisawa et al., 1998; Clouthier et al., 2000).
A pharmacokinetic study of activated charcoal has been performed on dogs showing substantial increases in serum osmolality and lactate following administration of activated charcoal doses typical of veterinary practice [ 51].
