Suggestions(2)
Exact(5)
Only after administration of particles are unique heterogeneities revealed, which are correlated histologically.
Quantitatively, the animals with tumors showed a much larger magnitude of change in normalized MRI value after administration of particles than the bladder walls of non-tumor, sham-injected negative control mice (Fig. 6).
Furthermore, a drastic reduction of plasma calcium concentration accompanied by calcium absorption and a dose-dependent enhancement of plasma interferon β concentration were observed after the administration of particles loaded with calcitonin or interferon β into closed rat ileal segments.
This ratio could potentially be present at the same point of time following the intravenous administration of particles, while the larger ratios are statistically less possible in in vivo conditions in the body.
The administration of particles by intratracheal instillation has the advantage of easy delivery of a well-defined dose of the compound of interest to the lungs but have disadvantages that must be mentioned.
Similar(55)
When the particle-treated cells received repeated administration of the particles or recovery from frozen storage, even when the cells grew on the surface coated with the particles, they still maintain proliferative activity, suggesting that the 6MP-AuNPs-RDP should have the potential for application.
These data suggest that administration of nanoclay particles causes liver injury.
In mice, administration of nanoclay particles via the tail vein led to acute liver injury.
(A) Body weight during 28-day oral administration of silica particles; plasma concentrations of (B) alanine aminotransferase (ALT) and (C) blood urea nitrogen (BUN).
Serum levels of the liver enzymes alanine aminotransferase (ALT) (a) and aspartate aminotransferase (AST) (b) were determined using commercially available kits (see Biochemical analyses section) 24 h after intravenous administration of nanoclay particles at the indicated doses.
—The administration of talc particles to the pleural space for the production of symphysis has been practiced for over 70 years with little understanding of the key particle parameters that lead to desired or undesired clinical outcomes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com