To confirm that the fibrosis induced by the segmental administration of bleomycin was localized to the specifically treated lobes, an ex-vivo CT scan was performed on lungs removed at autopsy (Fig. 2).
After systemic administration, PAMAM localized to the injured neurons and microglia in the brain of canines (Fig. 7b), allowing for the delivery of both NAC and valproic acid for enhanced neuroprotection [117].
Now, though, Toyota is a leading proponent of "localizing" its production to build cars closer to where they are sold.
Localized administration of immune modulating agents has been shown to lead to regression of cutaneous melanoma metastases in several phase II studies.
However, it was recently shown that Cowpea mosaic virus (CPMV) can enter the bloodstream after oral administration and can localize in endothelial cells of the blood brain barrier.
To determine whether intratumoral administration of Ad-IFNγ could achieve localized sustained expression of IFNγ, we sought to characterize the biodistribution of the adenoviral vector and transgene expression in the tumor, blood, liver, kidney, heart, brain, spleen, and lung at days 1, 2, 3, 5, 7, 14, and 21 after injection.
It has been our central hypothesis that localized and controlled administration of vector in the cornea via minimally invasive simple surgical techniques would allow targeted therapeutic gene delivery into desired cells of the cornea, in vivo.
Thus, localized hyperthermia after systemic administration of porphyrin labeled stealth MNPs may hold promise for future clinical therapy of melanomas.
Photodynamic therapy (PDT) is a non-thermal technique for producing localized tissue necrosis with light after prior administration of a photosensitizing drug and it could have a role in the local treatment of these cancers.
In Cohort 5, 4/15 CM developed a localized rash at the site of administration of SGE, two of which subsequently developed a disseminated rash on their abdomen, inner arms and legs.
