Suggestions(5)
Exact(14)
administration of bacteria.
Nevertheless, in blood we could detect TNF-α shortly after administration of bacteria (Fig. 3b).
The route of administration of bacteria may greatly affect the strength and type of adaptive immune response generated.
The results indicate that the low expression of TNFα is correlated with healthy status and not with the administration of bacteria.
The first biopsy from patients in the treatment group was taken before the administration of bacteria.
The recombinant protein could be detected locally shortly after administration of bacteria and persisted at measurable levels for several hours.
Similar(46)
How oral administration of probiotic bacteria can affect T cell mediated inflammation in remote skin tissue remains unclear.
Given the facts that administration of live bacteria through multiple routes replicates many of the characteristics seen in acute infections such as clinical sepsis [23] while chronic infections being a local insult are usually obtained in animals using bacteria products such as LPS or fimbria or very low concentration of live bacteria.
Indeed septic shock which is the epitome of acute infection in animals is mostly obtained after administration of live bacteria; in contrast the use of LPS to generate an endotoxic response requires the animals to be artificially pre-sensitized using drugs like D-galactosamine which inflict liver toxicity and does not mimic clinical settings [26], [27].
After administration of the bacteria suspension (t0), resuscitation maneuvers were performed following a defined algorithm.
A way of circumventing these issues is represented by the direct administration of recombinant bacteria, acting simultaneously as cell factory and delivery system for pharmacologically active proteins.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com