The phrase "administration localized" is correct and usable in written English.
It can be used in contexts discussing the decentralization or specific regional management of administrative functions or services.
Example: "The new policy emphasizes administration localized to better address the unique needs of each community."
Alternatives: "localized management" or "regional administration".
After systemic administration, PAMAM localized to the injured neurons and microglia in the brain of canines (Fig. 7b), allowing for the delivery of both NAC and valproic acid for enhanced neuroprotection [117].
The route of administration of bleomycin is known to influence the spatial distribution and evolution of fibrotic lesions, with intratracheal administration resulting in localized bronchiocentric lesions and oropharyngeal administration, as used in our study, causing diffuse peripheral, subpleural lesions (Scotton and Chambers, 2010).
Localized administration of immune modulating agents has been shown to lead to regression of cutaneous melanoma metastases in several phase II studies.
For localized pain conditions local administration has therefore been used with positive results [22, 23].
To confirm that the fibrosis induced by the segmental administration of bleomycin was localized to the specifically treated lobes, an ex-vivo CT scan was performed on lungs removed at autopsy (Fig. 2).
However, it was recently shown that Cowpea mosaic virus (CPMV) can enter the bloodstream after oral administration and can localize in endothelial cells of the blood brain barrier.
It has been our central hypothesis that localized and controlled administration of vector in the cornea via minimally invasive simple surgical techniques would allow targeted therapeutic gene delivery into desired cells of the cornea, in vivo.
Percutaneously absorbed NSAIDs have an analgesic effect, inhibit expression of c-Fos in the dorsal horn, and reduce PGE2 in inflamed tissue, indicating the efficacy of this method of administration for acute inflammation and localized pain.
This is of clinical importance as the inner-limiting membrane is the site of abnormal angiogenesis in both ROP and DR. With subretinal administration, VEGF Sticky-trap remains localized in the subretinal space, the site of abnormal angiogenesis in WMD.
Thus, localized hyperthermia after systemic administration of porphyrin labeled stealth MNPs may hold promise for future clinical therapy of melanomas.
The use of these dosage forms overcomes the administration problems, but they may cause localized effects, as blurred vision (e.g., ointments), or lack of patient compliance [ 19].
