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However, intravenous or intramuscular administration is difficult and inconvenient and may cause side effects.
Nevertheless, endotoxemia induces the innate immune system, as does sepsis, and investigating the timing of steroid administration is difficult to do in the clinical situation.
However it was noted that administration is difficult in children with mental retardation or behavioral issues.
However, intravenous administration is difficult to perform on swine due to inaccessible superficial veins and thick subcutaneous fat layers [ 25].
Despite being available for the last 70 years, leishmanial chemotherapy has lack of efficiency, since its route of administration is difficult and it can cause serious side effects, which results in the emergence of resistant cases.
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Direct estimates of wild mammal populations and the relationship of these to numbers of PEP administrations are difficult to obtain; this topic was beyond the scope of our review but needs research.
There was so much cross-pollination between the foundation and the administration, it is difficult to determine the degree to which one may have influenced the other.
Without working documents and with his asylum case rejected by the French administration, it is difficult to find a source of income, and he, like the many other bouquet-toting men from Pakistan, India, Bangladesh, and Sri Lanka, has taken to selling roses from bar to bar.
As it is not reported how the items were selected and who reviewed the measure before administration it is difficult to assess content and face validity.
Current treatments, however, are unsatisfactory due to toxicity, increasing treatment failures and the need for parenteral administration, which is difficult in a rural setting in Africa.
With such a low occurrence of premature administration, it is difficult to draw any meaningful distinctions among the programs, each of which had various and unique features in design.
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