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In this proof-of-principle therapeutic study we showed that VLP administration conferred protection against HgCl2-induced AKI, presumably via activation of the Akt-1 survival pathway and chaperones.
Kaplan Meier analysis showed that GSI administration conferred a significant survival benefit.
Others have identified GP88 by microarray analysis as being upregulated in doxorubicin-resistant breast cancer cells whereas GP88 exogenous administration conferred resistance to the killing effect of doxorubicin [ 4].
This relaxation of eligibility criteria permitted important data capture on abiraterone acetate's efficacy in a disease state of unmet need biochemical relapse and addressed the clinically relevant question of whether past ketoconazole administration conferred resistance to abiraterone acetate, given their similar mechanisms of action through CYP inhibition.
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Indeed, we showed that inhibition of Neu1 by either gene deletion or sialidase inhibitor administration confers a strong protection against endotoxemia.
Given that APC administration confers persistent long-term effects on overall survival [ 12] and its proposed relationship with inflammation, organ dysfunction and symptoms/functional status [ 13], it could plausibly influence long-term HRQoL.
Protection from kidney damage was coincident with the induction of Nrf2 and its target genes, while priming with Nrf2 inducers before FeNTA administration also conferred protection [48], [49].
On Capitol Hill, top House and Senate Republicans called on the administration to confer with lawmakers before any military strike and to make the case to a skeptical public.
Use of a long-lasting prophylactic as part of a mass drug administration regimen confers the most benefit under conditions of high transmission and moderately high coverage.
In vivo, repeated administration of EGCG conferred a dose-dependent protection against lethal endotoxaemia, and rescued mice from lethal sepsis even when the first dose of EGCG was given at >24 h after onset of sepsis (Ref. 84).
In all, a group of 40 entertainment executives and union representatives -- including the heads of the Warner Brothers television studio and the CBS and Fox television networks -- conferred with administration officials for about two hours on Wednesday in the Hollywood offices of the lawyer Bruce Ramer.
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CEO of Professional Science Editing for Scientists @ prosciediting.com