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However, curcumin administration at a dose of 100 mg/kg to PTZ animals prevented cognitive deficits.
Fentanyl administration at a dose of 20 μg increased the proportions of time with the PSI value less than 80.
administration at a dose of 3 30 nmol/mouse or 30 300 mg/kg, respectively, in fasted mice.
Novokinin lowered blood pressure in C57BL/6J mice after oral administration at a dose of 50 mg/kg.
This neurotoxic effect was markedly inhibited by melatonin administration at a dose of 5 mg kg− 1.
Among these, 15l effectively inhibited the production of serum TNF-α by oral administration at a dose of 30 mg/kg.
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The investigators found greater availability of selamectin in female beagles than in male following topical administration at a dose-rate of 6 mg/kg.
Forty patients received a total of 263 administrations at a cisplatin dose of 50 mg m−2, and 67 patients received 358 administrations at a dose of 70 mg m−2.
Moreover, T1/2 of ABZ-SO was significantly shorter in goats compared with that observed in sheep following IV and SC administrations at a dose of 5 mg/kg BW.
Therefore, the present study was designed to compare the pharmacokinetic and bioavailability of ABZ-SO in goats and sheep following IV and SC administrations at a dose rate of 5 mg/kg bodyweight (BW) and to investigate the effects of increased doses (10 and 15 mg/kg) on the plasma disposition of ABZ-SO in goats following SC administration.
In goats, the area under the curve, terminal half-life and plasma persistence of ABZ-SO were significantly smaller and shorter, respectively, compared with those observed in sheep following both IV and SC administrations at a dose of 5 mg/kg BW.
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