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Therapeutic drug monitoring allows us to adjust dose administrated based on Css in order to achieve optimal drug exposure for an individual patient.
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NFV and BZ were administrated simultaneously, based on preliminary data that the concurrent schedule showed similar effect to the sequential schedule (NFV followed by additional BZ treatment) in Supplementary Figure 6.
Remifentanil continuous infusion was administrated 25 µg/h/kg based on ideal body weight.
The method of H. tomentosa infusion preparation and the dose administrated was also based on methods applied in previous studies [ 6, 28- 30].
However, the present paper is an observational study, and the decision of administrating fluids was based on physicians' judgment, according to the needs of the single patient.
13Another justification for the sensitivity tests is that students are matched to teachers based on the teacher administrating the end of year tests.
We obtained information from the Swedish National Prescription Register [ 18], administrated by the Swedish Corporation of Pharmacies and based on record of sales.
The Dutch Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) is a rapid and easily administrated screening instrument to detect delirium and is based on the DSM-IV.
Based on these findings, ethanol was administrated at 4 mg/g body weight and osmotin at 15 μg/g body weight 30 min after ethanol treatment in the following experiments.
BQ-123 (Calbiochem, USA) at four dosages 15 μg, 20 μg, 25 μg, and 30 μg were each dissolved in sterile saline and administrated intrathecally in a bolus of 10 μL based on its usage in other pain-related studies [ 20, 21].
Here, we reported the efficacy and toxicity of another risk-adapted approach in administrating DLI as pre-emptive immunotherapy for childhood leukemia based on chimerism and donor source.
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