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Thus, multiple minimally invasive vector-delivery techniques to administer vector into keratocytes, stroma or endothelium of the rabbit and rodent cornea in vivo were optimized.

In the first phase I study, 14 subjects with RA and 1 with ankylosing spondylitis were administered vector [ 33].

As cone degeneration in Cngb3−/− mice occurs early, with decreased cone density already occurring at P30 (31, 31), we administered vector at P15 and evaluated cone survival ∼8 weeks PI.

Systemically administered vectors must cross the endothelial lining of tumor blood vessels to access cancer cells.

To use these strains as orally administered vectors to deliver other antigens we incorporated the B subunit of shiga-like toxin 1(Stx1) into the passenger domain of the autotransporter EspP expressed on a plasmid.

SGs are also capable of producing large amounts of proteins, and human SGs are well encapsulated, a circumstance likely to minimize the undesirable access of administered vectors and transgenes to other tissues [ 2].

We generated pseudotype tyrosine-mutant AAV9/3 vectors, administered the vectors to adult mice with intracardiac injections, and then evaluated brain transduction.

Improved immunogenicity and protective efficacy have also been observed in animal models using combination vaccination strategies, administering DNA vectors expressing mycobacterial HSPs in conjunction with cytokines or other mycobacterial proteins.

We administered Ad vector via retro-orbital sinus in both neonatal and adult mice although systemic administration of an Ad vector in adult mice is usually performed via tail vein injection.

Despite numerous attempts, the ability to re-administer AAV vector still represents an unmet goal for the field of in vivo gene transfer.

We created AAV2/5 expressing GFP alone or S1R-GFP-APEX2 (full-length) and administered the vector by an intrathecal injection.