Therefore, the identification of additional reliable markers could help to tailor radiation regimens in order to administer the optimal therapeutic dose while minimizing toxicity.
Therefore, the discovery and application of novel prognostic biomarkers could help predict clinical outcomes and administer the optimal therapy in the management of NSCLC patients.
The most important objective of staging is the exact detection of all nodal and extranodal lymphoma manifestations present to be able to administer the optimal therapy according to the stage and to the risk situation.
A limitation of that study was the use of cranberry juice as a nonstandardized preparation, so it is therefore unclear what dosage of proanthocyanidin was actually administered, the optimal dosage of which appears to be 36 mg/day.
A peptide dose of 15 μg was used because this amount is required to administer the optimal activity dose of 555 MBq Lu-DOTA,Tyr-octreotate in CA20948 tumour-bearing rats [ 21].
To assess the impact of protein amount administered on the optimal alpha-particle emitter choice, the time-integrated activity (TIA) for the tumor, blood, spleen, liver, kidneys, and thymus were calculated using the 111In-DTPA-anti-PD-L1-BC 111In-DTPA-anti-PD-L1-BC 111In-DTPA-anti-PD-L1-BC 111In-DTPA-anti-PD-L1-BC 111In-DTPA-anti-PD-L1-BC 111In-DTPA-anti-PD-L1-BC 1
For the intervention group, IFX may not have been administered at the optimal therapeutic dose or the exposure duration to the drug may not have been long enough.
However, further studies are needed to understand the full characteristics of the LLR, including its efficacy when administered following the optimal regimen, the potential risk of inducing intussusception, and the direct and indirect protective effects of LLR.
Again, NYCRIS collects only basic treatment details and this limited our ability to use pertinent and revealing outcome measures, for example, whether preoperative radiotherapy was administered at the optimal dosage to high-risk patients instead of whether it was given at all.
For the most commonly used antibiotics, it has been considered optimal to administer the drug intravenously 30 min before skin incision (Gyssens 1999, Polk and Christmas 2000) and it has been documented that administration more than 60 min preoperatively is associated with higher risk of surgical infection (Galandiuk et al. 1989).
