Your English writing platform
Discover LudwigExact(1)
High SA of 111In-labelled peptides and antibodies is required to administer a tracer dose of peptide or protein, preventing target saturation and/or side effects, while administering high activity doses required for imaging.
Similar(59)
We have, however, also previously shown that the peritoneal lining in mice may tolerate absorbed doses as high as 30 50 Gy [13], implying the possibility of administering higher activity concentration levels in humans.
High specific activities of 68Ga-labeled tracers are required to administer high activity doses in combination with low peptide doses.
Therefore, 68Ga-labeled peptides with a high specific activity should be produced to administer high activity doses at a low amount of peptide.
In general, the tracer doses administered in rodent models must be kept low while at the same time administering relatively high activity doses (> 10 MBq/animal).
Mice administered the low doses of LPS described above had relatively normal appearance and activity whereas mice administered higher doses (1 2 mg/kg) showed classic signs of sickness behavior including cachexia, diarrhea, lethargy and decreased grooming.
In contrast to the 0.0 g/kg dose that increased the activity over time, animals administered the low dose (0.5 g/kg) demonstrated an initial high activity followed by a decline over time.
In rodents, relatively high activity doses (3 10 MBq) have to be administered to acquire PET images with adequate image quality.
Find the area of high activity.
In is important to realize that even when high activities are administered in therapy procedures, the DT count losses are typically observed only in the first scan, done shortly after the injection.
Activity in SLNs was not found to correlate with the administered dose, and the highest activity was found in level II.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com