The treatment duration should be also mentioned, because in human IBD, thiopurines are often administered for years, and although it was long enough to cause liver injury in AZA treated mice, nine days may not be a relevant time for induction of NRH.
Bisphosphonates as a class should be administered for 3 5 years and then discontinued in lower-risk subjects, e.g., the 'bisphosphonate drug holiday'.
Fourth, in our study, tamoxifen was administered for 2 years only, while the optimal duration of such a treatment is now known to be 5 years.
The chronic nature of most seizure disorders requires that antiepileptic drugs (AEDs) be administered for many years.
Tonya Jackson Smallwood, president of Family Matters of Greater Washington, testified that her organization will soon have to stop administering a District-wide safety net program that it has administered for 30 years.
In an unusual intervention, the United Nations secretary general, Kofi Annan, came to the Security Council to appeal for a solution that would not compromise the future of peacekeeping operations, which he administered for many years.
Another devastating setback was the loss of the region of Poitou-Charentes, which Mr. Raffarin administered for 14 years before Mr. Chirac lifted him from provincial obscurity and appointed him prime minister after the 2002 election.
Typically, chemicals are administered for two years to both sexes in each of one strain of rats and mice generally at the maximum tolerated dose (MTD), MTD/2, MTD/4 (in recent years), as well as unexposed control animals.
Galiwinku was administered for many years by an Aboriginal town council, but in 2008 the entire region was absorbed into East Arnhem shire (now East Arnhem region), which assumed responsibility for local government.
Adjuvant 5′-deoxy-5-fluorouridine was orally administered for 2 years after the operation.
