Interestingly, when rats were administered an equivalent dose based on CW (46 mg/kg) the levels of hASM attained in the majority of CNS regions analyzed were fairly comparable between species (Figure 4a, 4b).
Half of the rats in each group (n = 4 and 3 in Px and Shams, respectively) were administered, via oral gavage, standardized volumes of the solution (0.48 g of L-Leucine per kg of body weight) while the other half were administered an equivalent volume of water (24 mL/kg).
Control groups were administered an equivalent volume of sterile saline.
The animals in CON group were administered an equivalent amount of normal saline.
For every time point, separate groups of control mice were either left untreated or administered an equivalent amount of a non-specific isotype control antibody.
Meanwhile, rats from the solvent-control-, ICI- and E2-treated groups were administered an equivalent volume of corn oil without BPA or E2.
At dose/schedules that administered an approximately equivalent cumulative dose of darbepoetin alpha, the impact on haemoglobin variables was broadly similar, for example, haematopoietic response was achieved by 70%95%CI=53=53, 88) of patients at 2.25 μg kg−1 QW; by 60%95%CI=36=36, 83) at 6.75 μg kg−1 Q3W; and by 70%95%CI=50=50, 91) at 10 μg kg−1 Q4W.
Eleven days later, the patient was administered a teaspoon equivalent to 400 to 500 mg of carbachol (the average parenteral therapeutic dose is 1 mg).
Bufalin-loaded liposomes, bufalin-loaded PEGylated liposomes, and bufalin in aqueous suspension-assisted solubilization by ethanol were prepared as previously described and then intravenously administered at an equivalent dose of 0.5 mg/kg, respectively.
To do this, the Trickle 5 group were administered with an equivalent of 5 iL3s per day by infection on days 0, 3, 7, 10, 14, 17, 21, 24, 28 and 31 post infection (p.i).
