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The mRNA expression and the enzyme activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase significantly increased only in livers of rats of Group V. Furthermore, high mRNA expression of P2 receptors and caveolin were found in aorta of rats administered with high dose of methionine (Group IV and V at 8 weeks).
INO may contribute to the formation of cytotoxic reactive nitrogen species and reactive oxygen species, especially when administered with high concentrations of oxygen [27].
However, an animal study reported a slightly higher incidence of early intrauterine deaths in rabbit foetuses whose mothers had been administered with high doses of intravenous gadobenate dimeglumine [9].
Yet even if the points system is administered with high discretion and within the bounds of the law, it still leaves workers in a terrible position.
Sevoflurane was administered with high fresh gas flow (10 l.min-1, FiO2 = 0.3).
The Gambia EPI is one of the most successful in sub-Saharan Africa with up to ten vaccines being administered with high coverage rates.
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Several chemotherapy regimens yield better survival when administered with higher frequency and dose.
Sections from the rat testis administered with high-dose hair dye for 8 days showed more shrinkage and deformity of seminiferous tubule, wide interstitial spaces, and dilatation and congestion of blood vessels.
Sections from the rat testis administered with high-dose hair dye for 8 days show the following: (a) more shrinkage and deformity of seminiferous tubule, wide interstitial spaces, and dilatation and congestion of blood vessels (H-E, × 200).
Open image in new window Fig. 7 Sections from the rat testis administered with high-dose hair dye for 8 days show the following: a more shrinkage (black arrows) and deformity (white arrows) of seminiferous tubule, wide interstitial spaces (black stars), and dilatation and congestion of blood vessels (dotted arrows) (H-E, × 200).
The potential for the modification of the pharmacokinetics of doxorubicin (DOX) concurrently administered with high-dose verapamil (VER) has been investigated in 17 patients with advanced neoplasms refractory to drugs belonging to the multidrug resistance spectrum.
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