The objective of these studies was to determine the activity of two alternative 4- drug combinations using cis-retinoic acid or thalidomide administered with a previously developed combination of 5 fluorouracil, interferon-α, and interleukin 2 (FUNIL), for patients with metastatic renal cell carcinoma (RRC).
Physician or nurse sedationists administered sedation with a combination of fentanyl, midazolam and propofol.
This may be related to the doubling of the amount of influenza antigens administered with the combination vaccine and the adjuvant-effect associated with the viral components.
When administered with FVAX, combination co-stimulatory modulation promoted rejection in 57% of B16 melanoma challenged mice versus 20% and 13% for αCTLA-4 and α4-1BB alone (Figure 1A).
C57BL/6 mice were intradermally administered with CRT/E7 in combination with either bic 155 or a control construct.
Tamsulosin should be administered with caution in combination with cimetidine due to significant (26%) decrease in the clearance of tamsulosin.
These findings raise the concern that phenylephrine administered as a combination with paracetamol may increase the incidence of adverse effects attributable to phenylephrine, most notably cardiovascular adverse effects particularly those with preexisting cardiovascular conditions.
It is noteworthy that most of subsequent platinum was administered as a combination regimen, with a similar proportion between arms: 80% (PLD arm) and 82% (trabectedin/PLD arm).
Four to 6 weeks after the surgical procedure, all patients with a first diagnosis of HGG were administered the "Stupp protocol" with a combination of radiation therapy and temozolomide, followed, after a 4-week rest period, by temozolomide alone.
If chemotherapy is prescribed, it is recommended to administer a combination therapy with two drugs, containing cisplatin (recommendation, expert agreement) for patients with a good general health status (WHO performance status of 1 or less).
