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Experts had predicted for months that, because the H1N1 swine flu has never been seen before by human immune systems, it would take two doses, administered weeks apart, to get a "take" — antibody levels as high as those produced by regular flu shots.
While it is rare that patients report symptoms of envenomation lasting weeks or month following a bite, there are case reports from the 1990s in which antivenom was reported to be effective in the relief of chronic symptoms when administered weeks or months after a bite, however, in the vast majority of cases, it is administered within 24 hours.
If multiple dose studies are carried out, the radiopharmaceutical is administered weeks apart and, from a toxicological stand-point, is, therefore, considered equivalent to a single dose.
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We are also presenting the cumulative safety data for the entire study up to the last dose administered (week 104).
Each macaque received 3 doses (prime and 2 boosts) administered 8 weeks apart (weeks 0, 8, 16).
Infliximab was administered at weeks 1, 3 and 7 and then every 4 weeks.
Additional infusions are administered two and six weeks after the initial infusion and at eight-week intervals thereafter.
Four injections were administered at weeks 0, 4, 12, and 24, with permission to administer additional injections at weeks 36, 48, 60 and 72.
Bleomycin and saline were first administered at week −2 and repeated two weeks later at week 0. (Fig. 1b).
The posttest was administered 2 weeks after the pretest.
Booster doses were administered 4 weeks after the initial immunization.
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