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Ease of administration may be accomplished by the introduction of room temperature stable products and the development of subcutaneous and even orally administered therapeutics.
Increasing the dose of systemically administered therapeutics has the potential to increase intracerebral drug delivery.
In patients with signs of progressive hepatic impairment and threatening hepatic failure, liver function was evaluated to avoid overdosage of administered therapeutics.
A wide assortment of antibacterial polymers exists, but the majority are based on various inorganic functionalities rather than on classical, internally administered therapeutics.
Similar(56)
The development of oral drug delivery platforms for administering therapeutics in a safe and effective manner across the gastrointestinal epithelium is of much importance.
Ultrasound technology in combination with echogenic particles is currently having a considerable effect on the modern medical field, not only as a conventional diagnostic modality but also as a methodology that administers therapeutics to various lesions.
The current clinical progress of systemically administered siRNA therapeutics is reviewed, with special attention to the toxicity profiles associated with RNAi nanomedicines.
An example of great interest and potential is the development of an siRNA drug candidate against RSV, where clinical trails demonstrated that low dosages of inhaled uncomplexed siRNA are a potent and easy way to administer antiviral therapeutics against respiratory viral diseases in humans (www.alnylam.com).
This has been mainly attributed to inadequacies of approaches available to administer the therapeutics moieties, such that they will reach the target tumor site in their most potent form with minimal collateral damage.
Therapeutics administered as soluble injections often require high doses and frequent re-dosing, which can result in systemic toxicities.
Small mammals usually eliminate drugs faster than large mammals [44], and toxic endpoints for therapeutics administered systemically to animals scale well between species when doses are normalized to body surface area [45].
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Justyna Jupowicz-Kozak
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