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Separately, testosterone and DFMO each have been administered previously to humans for other indications.
Cytokine therapy had been administered previously to five patients, and most patients (14 of 16 patients) had undergone previous nephrectomy.
Furthermore, testosterone and DFMO have been administered previously to humans and approved by FDA for other indications; therefore, they provide an accelerated path to clinical application.
If at least one dose of PPV23 has been administered previously, a dose of PCV13 is recommended one year after the last PPV23 dose.
It has been administered previously in both acute and chronic experimental models of liver injury and systemic inflammation, showing efficacy and a safe profile [ 32] with an ID50 of 2.9-0.4 2.9-0.4intramuscular) in rats [ 13].
Patients pretreated with taxanes could be enrolled in the trial if relapsed more than 6 months after taxanes used in neoadjuvant/adjuvant setting, or more than 3 months in metastatic disease who had documented responses when taxane administered previously.
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A range of patient-reported outcomes will be collected from all participants by regularly administering previously validated surveys at baseline, 6 and 12 months.
On 16 January of this year, Dennis McGuire took 26 minutes to die in Ohio, desperately gasping for air throughout, after being administered a previously untested combination of midazolam and the painkiller hydromorphone.
Cyclosporine, corticosteroids and azathioprine were administered as previously reported [37].
Unfortunately, vaccination can result in severe local or systemic adverse reactions when administered to previously infected populations, and repeat vaccination can induce severe persistent reactions [4], [5].
Nutritional support is administered as previously described [ 23].
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