They are, however, preliminary, and it remains to be seen whether a more rigorous procedure, administered over longer periods of time, would lead to longer lasting reductions in smoking.
Finally, our data also suggest that there may be benefits in using dual mTORC1/2 catalytic inhibitors if administered over longer periods, as these may result in inhibiting autophagy, which may decrease viability of at least some types of cancers (43, 45, 46).
Unlike the study with -CPP, the PPF was administered over a longer term (that is, once daily for 10 consecutive days) to ensure that the glia became inactive.
A view was shared that future protocols should be more pragmatic and in particular allow a greater number of treatments to be administered over a longer period of time, and allow treatments to be individualised.
Of note, even with the low dose of IDS administered over the longer time interval (1.2 mg/kg once every 7 days), there was good clearance of GAGs in all of the regions of the brain analyzed.
When a constant concentration x time level was employed, a short-term exposure to a high concentration produced a greater effect than exposure to a lower concentration administered over a longer period.
Though we believe that a time weighted measure is the best way to measure total satisfaction with pain relief, pain relief was administered over a longer period of time in the epidural analgesia group.
It can be seen that in shorter treatment regimens (5 days overall treatment time) the respective effect of 1 Gy administered is higher for tumour than for normal tissue, because a much smaller total dose achieves an effect upon the tumour that would require a higher total dose, if administered over a longer overall treatment time (Table 5b).
An alternative or additional explanation may be the IV lidocaine loading dose was administered over a longer period of time in the study of Doherty & Frazier [ 17] (i.e., 15 minutes versus 5 minutes in the presently reported study) and resulted in a lower peak lidocaine plasma concentration.
Finally, we tested only a single dose of insulin, and therefore it is unclear whether lower or higher doses could be more effective and whether this dose may lead to long-term improvement of memory if administered over a longer period of time.
The planned study will enable the CAT to be administered over a longer period of time with carers, enabling the team to follow alert changes and the actions taken to support the carer, in addition to conducting validity test-retest and reliability scale coefficient analysis.
