A second set of simulations was performed for 17 piperacillin regimens between 0 and 20 g three times daily, administered by bolus or extended infusion.
Because HER2-targeted drugs may be administered for extended periods of time and in combination with other systemic therapies, biosimilars have the potential to result in significant savings for healthcare systems.
Sequential dosing may be particularly useful for ABT-263, as it cannot be administered for extended periods of time due to its severe toxicity on platelets.
Thus, this model could be used to examine which cART treatments are the least neurotoxic when administered over extended periods of time.
We speculated that the differences in the antiremodeling effect between these two doses are likely to be significant if resveratrol is administered over extended periods of time.
Moreover, the utilization of higher doses of meropenem administered as extended infusions further increased the probability of achieving bactericidal exposures for this resistant population of organisms.
A potential problem associated with targeting human enzymes is the toxicity of the compounds; however, this has not prevented the registration of kinase inhibitors for cancer treatment, even though anticancer agents must generally be administered for extended periods of time.
Furthermore, a 2 year prospective study of over 20 000 patients treated with pitavastatin revealed no unexpected negative side effects of treatment [33], confirming the general long-term safety and tolerability of statins, as observed for atorvastatin [34], simvastatin [34] and rosuvastatin [35] administered for extended periods in previous studies.
The aim of this study was to assess the influence of augmented renal clearance on pharmacokinetic/pharmacodynamic target attainment in critically ill patients receiving meropenem or piperacillin/tazobactam, administered as an extended infusion.
Within the Community, members' rights can be administered, adjudicated, and extended by common institutions, including the European Commission, Council of Ministers, Court of Justice, and Parliament.
By 2016, IPG had a cutting-edge genomic sequencing laboratory that provided sequencing services to Intermountain and non-Intermountain physicians, and IPG's team had conducted research indicating that targeted therapies administered through IPG extended patient lifespans but increased overall costs.
