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Consequently, chemotherapy could be administered on schedule, and side effects were minimal and acceptable.
In all, 90% of the 69 cycles of combined PEG-LD and valspodar were administered on schedule.
Chemotherapy was administered on schedule if neutrophil count was ≥ 1.5 × 10/L (normal range: 2 7.5) and the platelet count ≥ 100 × 10/L (normal range: 140 450).
This open-label, multicentre, phase II trial conducted in the United States and Europe analysed sunitinib administered on Schedule 4/2 and on a CDD schedule.
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A total of 72 patients were entered onto the two concurrent phase I studies of temozolomide administered on Schedules A and B. For Schedule A, the maximum tolerated dose (MTD) of temozolomide was determined to be 150 mg m−2 day−1 for 7 days every 2 weeks for both minimally and heavily pretreated patients (Figueroa et al, 2000).
When administered on this schedule, the pharmacokinetics of total doxorubicin in combination with valspodar was moderately affected.
In conclusion, docetaxel, administered on this schedule, did not show significant anti-tumour activity in patients with metastatic PC. © 1999 Cancer Research Campaign.
PCV7 was licensed on the basis of a randomized controlled trial in The Northern California Kaiser Permanente health care system, which demonstrated 97% efficacy against PCV7-serotype IPD when administered on a schedule of dosing at 2, 4, 6, and 12 15 months of age (9 ).
The results of the current study support the assertion of Brock et al (1998) that cumulative 'schedule-dependent' inactivation of AGAT is, in part, responsible for the level of activity noted in preliminary studies of temozolomide administered on protracted schedules.
Although the four TKIs utilised in this study target similar signalling pathways, the agents are administered on different schedules (see Table 2) and they differ subtly in their potency against individual receptors (see Table 3).
However, these effects were achieved only when the topisomerase I inhibitor (for example, topotecan) was administered on a daily schedule, and not when the drug was given on an intermittent schedule [ 11].
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