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Properly administered need to know and compartmentalization protects any major theft of information particularly if the data itself is stored in an encrypted format.
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Conventional drugs obey set of rules such as Lipinski's Rule-of-Five (RO5) [15], wherein all orally administered molecules need to have certain physiochemical properties.
Fentanyl (25 μg) was administered three times during the operation and phenylephrine (0.025 mg) was administered when needed to maintain blood pressure.
Isoflurane was administered as needed to maintain pre-CPB hemodynamics near preoperative baseline values.
Heparin was administered as needed to maintain a blood activated clotting time above 300 s.
An additional 0.5 mg/kg bolus was administered as needed to achieve the designed conscious level.
Heparin was administered as needed to maintain this value throughout the perfusion.
During surgery, supplemental intravenous doses of propofol were administered as needed to maintain adequate anesthesia.
Standard of care premedication will be administered as needed to patients receiving intravenous chemotherapy, including dexamethasone, acid suppressors, anti-emetics, analgetics and antipyretics.
Can it be properly administered, does it need to be looked at?
In order to have a beneficial effect on retinal degeneration a systemically administered inhibitor would need to cross the blood retinal barrier (e.g. HSP990).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com