Sentence examples for administered long term from inspiring English sources

However, as bisphosphonates are administered long term, there is increasing interest in their effects on bone quality, which includes bone mass, strength and architecture.

Most of the currently available transgene control modalities have been designed to be responsive to clinically licensed pharmacologically active drugs which were expected to prevail in future clinical trials yet raised concerns about side effects when administered long term at subclinical doses.

However, when rituximab is used in cohorts with high prior immunosuppressive exposure, where stem cell and plasma cell compartments maybe compromised, or when rituximab is administered long term using repeat dosing strategies resulting in prolonged B cell depletion, pre-existing humoral immunity maybe impaired.

In case of detrusor muscle overactivity, oxybutynin or solifenacin succinate was administered long-term until subjective well-being was observed on urodynamic examination.

However HRT, especially if administered long-term, may lead to an increased risk of breast and, when unopposed by progestins, endometrial cancers.

32 Moreover, estrogen replacement, especially if administered long-term, may lead to an increased risk of breast and, when unopposed by progestins, endometrial cancers.

Although retinoids are known to be inhibitory to breast cancer cell growth, a key remaining question is whether they would remain effective if administered long-term.

Since rapamycin is now a standard immunosuppressant used to maintain an organ transplant in children, linear growth may be affected if rapamycin is administered long-term to young and growing patients.

It is thought that psychotropic medication, particularly antipsychotic drugs, are prescribed all too often for these individuals and may be administered long-term [ 13– 15].The justification for their use in the absence of an ICD or DSM psychiatric disorder is commonly cited as an improvement in mood dysregulation.

Hurwitz and colleagues [ 37] reported the occurrence of fatal or near-fatal sepsis in 16 of 38 children with newly diagnosed acute lymphoblastic leukemia (ALL) treated with a new induction regimen that differed from its predecessor in that it administered long-term high-dose dexamethasone.

Because this was the first attempt to evaluate the effects of ARA on PPI, we administered ARA long term to obtain an unequivocal and maximum outcome.