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Both interventions were supplementary to standard care and administered in the initial stage of treatment in an ICU [ 23].
Additionally, glucocorticoids administered in the initial, acute phase of community acquired pneumonia were not recorded in our study and therefore could not be accounted for in the analysis.
Several recent studies [ 23, 33, 34], notably in children, have investigated neurosensory sequelae and mortality of a short corticoid treatment administered in the initial phase of bacterial meningitis.
Moreover, DDFPe is stable when stored at room temperature which makes it an ideal candidate for future development into clinical practice as it may be administered in the initial treatment of ischemic events by first responders.
Items were selected from the courses' summative exams administered in the initial two years of the program, which had acceptable psychometric characteristics and covered the courses' content through a test blueprint obtained by consensus.
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Once at the follow-up facility, clinical case scenarios, knowledge tests, and physical exams were administered in the same manner as the initial assessment, using a random selection of cases and test questions for both the clinical cases and knowledge tests.
While resuscitation with intravenous fluid and other agents to defined clinical goals is an important element of sepsis management, we have previously demonstrated in our patients that the total amount of fluid administered in the first 24 h of the initial resuscitation is not an independent risk factor for adverse clinical outcomes [34].
While resuscitation with intravenous fluid and other agents to defined clinical goals is an important element of sepsis management, we have previously demonstrated in our patients that the total amount of fluid administered in the first 24 h of the initial resuscitation is not an independent risk factor for adverse clinical outcomes [ 34].
The appropriateness of the initial dose of antibiotics administered in the ED was assessed in retrospect as is summarized in Additional file 3.
Other aspects of ED treatment, such as the amount of administered oxygen and fluids and the appropriateness of the initial dose of antibiotics administered in the ED, were associated with relevant clinical outcomes which may provide important directives for future studies.
Additional file 3: Flow diagram of the definition of the appropriateness of initial dose of antibiotics administered in the emergency department.
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