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For final validation the questionnaire was administered in phase 2 to 99 women.
Increasing doses of temozolomide and lomustine were administered in phase I of the study to determine the MTD.
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Analysis in the diets was performed in pooled samples of the diets administered in phases I and II.
A crossover design using a vegan diet and an unrestricted diet, each lasting two menstrual cycles, was used.Three-day dietary records and a quantitative instrument rating diet acceptability and perceived benefits and adverse effects were administered in each phase.
The age range, and thus the doses administered, in the phase I study population are not different to that studied here.
The trifunctional antibody catumaxomab (anti-Ep-CAM × anti-CD3) has been safely administered in a phase I/II study to patients suffering from malignant ascites (Stroehlein et al, 2005).
These monkeys received roughly 15 250 times the highest dose administered in the phase 2 trial (and 70 900 times more than the most effective dose determined by this trial, which was not the highest).
In contrast to the phase 1 study where 800 mg dosing was permitted, no grade 3/4 amylase elevations were observed at the 400 mg or 500 mg doses administered in this phase 2 study; asymptomatic grade 3/4 lipase elevations were recorded in a few patients and were reversible with dose reduction.
The treatments were administered in a phase-response curve experiment establishing the direction and magnitude of phase-shift depending upon the time of treatment.
The Rorschach method consists of ten cards with multicolored, symmetrical inkblots, administered in two phases: First, participants respond to what the blots look like and then a clarification is conducted regarding what gave that idea.
RUDIN: You say in your introduction to the best practices: Codes of ethics and practice standards are generally developed and administered in four phases: i.e.: discussion and analysis, recommended practices, required practices and verification or enforcement.
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CEO of Professional Science Editing for Scientists @ prosciediting.com